PHX2A Polyclonal Antibody

The protein encoded by this gene contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product. The encoded protein plays a central role in development of the autonomic nervous system. It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes essential for the differentiation and maintenance of the noradrenergic neurotransmitter phenotype. The encoded protein has also been shown to regulate transcription of the alpha3 nicotinic acetylcholine receptor gene. Mutations in this gene have been associated with autosomal recessive congenital fibrosis of the extraocular muscles.

The PHX2A Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of PHX2A protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of the human PHX2A protein. The resulting polyclonal antibody exhibits high affinity and specificity towards the target protein, making it an ideal tool for various applications in research and diagnostics.

The PHX2A Polyclonal Antibody is suitable for use in Western blotting, immunohistochemistry, and immunofluorescence assays. It has been validated for use in human, mouse, and rat samples, and has been shown to detect endogenous PHX2A protein in various tissues and cell lines. This antibody is supplied as a purified IgG fraction, and has been tested for its specificity and sensitivity in various applications.

The PHX2A Polyclonal Antibody is a valuable tool for researchers studying the role of PHX2A in various biological processes, including cell proliferation, differentiation, and apoptosis. It can also be used in clinical settings for the diagnosis and monitoring of diseases associated with PHX2A dysregulation. With its high specificity and sensitivity, this antibody is a reliable and effective reagent for a wide range of applications in the life sciences.