PDGFR-beta(Phospho Tyr740) Polyclonal Antibody

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.

The PDGFR-beta(Phospho Tyr740) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of PDGFR-beta protein phosphorylated at tyrosine 740. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity for the target protein.

PDGFR-beta, also known as platelet-derived growth factor receptor beta, is a transmembrane receptor tyrosine kinase that plays a crucial role in various cellular processes, including cell proliferation, differentiation, and migration. Phosphorylation of tyrosine 740 is a key event in the activation of PDGFR-beta and subsequent downstream signaling pathways.

The PDGFR-beta(Phospho Tyr740) Polyclonal Antibody has been rigorously validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits excellent sensitivity and specificity, enabling accurate and reliable detection of phosphorylated PDGFR-beta in complex biological samples.

This antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and quantity, ensuring cost-effectiveness and minimizing waste. The PDGFR-beta(Phospho Tyr740) Polyclonal Antibody is compatible with a wide range of experimental conditions and can be used in both research and clinical settings.

In summary, the PDGFR-beta(Phospho Tyr740) Polyclonal Antibody is a valuable tool for studying the phosphorylation status of PDGFR-beta and its role in various cellular processes. Its high specificity, sensitivity, and versatility make it an essential component of any research or diagnostic laboratory.