PDE1A Polyclonal Antibody

Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001

The PDE1A Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphodiesterase 1A (PDE1A) protein in various biological samples. This antibody has been meticulously developed using advanced techniques to ensure exceptional performance and reliability.

Phosphodiesterase 1A is an enzyme that plays a crucial role in the regulation of intracellular levels of cyclic nucleotides, particularly cAMP and cGMP. Dysregulation of PDE1A has been implicated in various diseases, including cardiovascular disorders, neurological disorders, and cancer. Therefore, accurate measurement of PDE1A protein levels is of utmost importance in understanding its physiological and pathological functions.

The PDE1A Polyclonal Antibody exhibits high affinity and specificity towards PDE1A protein, enabling precise detection and quantification in a wide range of sample types, including cell lysates, tissue homogenates, and biological fluids. This antibody has been rigorously validated through multiple experimental approaches, ensuring its reliability and reproducibility.

Furthermore, the PDE1A Polyclonal Antibody demonstrates excellent sensitivity, allowing for the detection of low-abundance PDE1A protein levels. This attribute is particularly advantageous when working with limited sample volumes or samples with low protein concentrations.

The PDE1A Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is recommended for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. The antibody has been optimized for compatibility with commonly used detection systems, facilitating seamless integration into existing experimental protocols.

In summary, the PDE1A Polyclonal Antibody is a highly reliable and sensitive tool for the detection and quantification of PDE1A protein. Its exceptional performance, specificity, and sensitivity make it an invaluable asset for researchers and scientists studying the role of PDE1A in various physiological and pathological processes.