PARP9 Polyclonal Antibody

Catalytic activity:NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.,miscellaneous:Overexpressed at significantly higher levels in fatal high-risk diffuse large B-cell lymphomas (DLB-CL) compared to cured low-risk tumors. Overexpression in B-cell lymphoma transfectants may promote malignant B-cell migration.,Contains 1 PARP catalytic domain.,Contains 2 Macro domains.,subunit:Interacts with BBAP.,tissue specificity:Expressed in lymphocyte-rich tissues, spleen, lymph nodes, peripheral blood lymphocytes and colonic mucosa. Also expressed in nonhematopoietic tissues such as heart and skeletal muscle. Isoform 2 is the predominant form.,

The PARP9 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of PARP9 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human PARP9 protein. The antibody has been purified using protein A affinity chromatography and is supplied as a liquid in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

The PARP9 Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It recognizes endogenous levels of PARP9 protein in human, mouse, and rat tissues and cell lines. The antibody has been shown to be highly specific, with no cross-reactivity with other PARP family members.

This antibody is an essential tool for researchers studying the role of PARP9 in various biological processes, including DNA damage repair, transcriptional regulation, and immune response. It can be used to investigate the expression and localization of PARP9 protein in different tissues and cell types, as well as to study the interaction of PARP9 with other proteins.

In summary, the PARP9 Polyclonal Antibody is a reliable and high-quality reagent that provides accurate and reproducible results in various applications. Its specificity and sensitivity make it an ideal tool for researchers studying the function of PARP9 in different biological contexts.