PARP-1 Polyclonal Antibody

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

The PARP-1 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of PARP-1 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human PARP-1 protein. The antibody has been purified using protein A affinity chromatography and is supplied as a liquid in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

The PARP-1 Polyclonal Antibody has been extensively validated for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been shown to specifically recognize PARP-1 protein in human, mouse, and rat tissues, making it a versatile tool for researchers studying PARP-1 function in different species.

This antibody has a high affinity and specificity for PARP-1 protein, making it an ideal choice for detecting low levels of PARP-1 expression in biological samples. It has also been shown to be highly reproducible, providing consistent results across multiple experiments.

In summary, the PARP-1 Polyclonal Antibody is a reliable and sensitive tool for the detection of PARP-1 protein in various biological samples. Its high specificity and sensitivity make it an ideal choice for researchers studying PARP-1 function in different species and in various applications.