Parkin(Phospho Ser131) Polyclonal Antibody

The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.

The Parkin(Phospho Ser131) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Parkin protein phosphorylated at Serine 131. This antibody is produced using advanced techniques and high-quality materials to ensure optimal performance and reliability.

Parkin is a crucial protein involved in the regulation of mitochondrial homeostasis and the maintenance of cellular integrity. Phosphorylation of Parkin at Serine 131 has been shown to play a significant role in its activation and subsequent recruitment to damaged mitochondria for degradation. Therefore, the detection and quantification of phosphorylated Parkin at Serine 131 is of great importance in understanding the molecular mechanisms underlying mitochondrial dysfunction and neurodegenerative diseases.

The Parkin(Phospho Ser131) Polyclonal Antibody exhibits exceptional specificity and sensitivity, enabling accurate and reliable detection of phosphorylated Parkin at Serine 131 in various experimental settings. It has been extensively validated for use in Western blotting, immunoprecipitation, immunofluorescence, and immunohistochemistry applications.

This antibody is supplied as a liquid formulation in a convenient size, allowing for easy handling and storage. It is provided in a ready-to-use format, eliminating the need for additional reagents or preparations. The Parkin(Phospho Ser131) Polyclonal Antibody is compatible with a wide range of sample types, including cell lysates, tissue extracts, and purified proteins.

In summary, the Parkin(Phospho Ser131) Polyclonal Antibody is a reliable and efficient tool for the detection and analysis of phosphorylated Parkin at Serine 131. Its high specificity, sensitivity, and versatility make it an invaluable asset for researchers studying mitochondrial dysfunction, neurodegenerative diseases, and related fields.