PAR4 Polyclonal Antibody

The tumor suppressor WT1 represses and activates transcription. The protein encoded by this gene is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells.

The PAR4 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Protease-Activated Receptor 4 (PAR4) in various biological samples. This antibody is produced using state-of-the-art technology and rigorous quality control measures to ensure optimal performance and reliability.

PAR4 is a G-protein coupled receptor that plays a crucial role in mediating cellular responses to thrombin, a key enzyme involved in blood coagulation. It is widely expressed in various tissues and cell types, including platelets, endothelial cells, and smooth muscle cells. Dysregulation of PAR4 signaling has been implicated in numerous pathological conditions, such as thrombosis, inflammation, and cancer.

The PAR4 Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various experimental settings, including Western blotting, immunohistochemistry, and flow cytometry. It exhibits minimal cross-reactivity with other PAR family members, ensuring accurate and reliable detection of PAR4.

This antibody is supplied as a purified and lyophilized formulation, allowing for long-term storage and convenient reconstitution. It is recommended for use in both basic research and clinical applications, providing valuable insights into the role of PAR4 in physiological and pathological processes.

In summary, the PAR4 Polyclonal Antibody is a highly reliable and specific tool for the detection and analysis of PAR4. Its exceptional performance and versatility make it an essential component in any research or diagnostic laboratory aiming to investigate the intricate mechanisms underlying PAR4 signaling.