p53(Phospho-Ser366) Polyclonal Antibody

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277).

The p53(Phospho Ser366) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated serine 366 residue on the p53 protein. This antibody is produced using advanced polyclonal antibody production techniques, ensuring high affinity and specificity towards the target epitope.

The p53 protein is a crucial tumor suppressor that plays a pivotal role in regulating cell cycle progression, DNA repair, and apoptosis. Phosphorylation of serine 366 residue on p53 has been implicated in various cellular processes, including DNA damage response and cell cycle arrest. Therefore, the ability to accurately detect and quantify phosphorylated serine 366 residue on p53 is of utmost importance in understanding the molecular mechanisms underlying these processes.

The p53(Phospho Ser366) Polyclonal Antibody exhibits exceptional sensitivity and specificity, enabling reliable detection and quantification of phosphorylated serine 366 residue on p53 in various sample types, including cell lysates and tissue extracts. This antibody has been extensively validated through rigorous quality control measures, ensuring consistent and reproducible results.

Furthermore, the p53(Phospho Ser366) Polyclonal Antibody demonstrates excellent performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. Its versatility allows for the investigation of phosphorylated serine 366 residue on p53 in different experimental settings, facilitating a comprehensive understanding of its functional significance.

In summary, the p53(Phospho Ser366) Polyclonal Antibody is a reliable and robust tool for the detection and quantification of phosphorylated serine 366 residue on the p53 protein. Its high specificity, sensitivity, and versatility make it an invaluable asset for researchers studying the intricate molecular pathways involving p53 and its phosphorylation events.