p53(Phospho Thr81) Polyclonal Antibody

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277).

The p53(Phospho Thr81) Polyclonal Antibody is a highly specific and sensitive tool for the detection and analysis of p53 protein phosphorylated at threonine 81. This antibody is produced using advanced techniques and high-quality materials to ensure optimal performance and reliability.

The p53 protein plays a crucial role in regulating cell cycle progression, DNA repair, and apoptosis. Phosphorylation of p53 at threonine 81 has been shown to modulate its transcriptional activity and stability, making it an important post-translational modification for studying p53 function.

This polyclonal antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with non-phosphorylated p53 and other related proteins, ensuring accurate and reliable results.

With its high affinity and specificity, the p53(Phospho Thr81) Polyclonal Antibody is an essential tool for researchers studying p53 signaling pathways, cancer biology, and other related fields. Its superior performance and consistent results make it a valuable asset in any laboratory setting.

Order your p53(Phospho Thr81) Polyclonal Antibody today and unlock new insights into the intricate mechanisms of p53 regulation and its implications in various biological processes.