p53(Phospho Thr387) Polyclonal Antibody

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277).

The p53(Phospho Thr387) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated p53 at threonine 387. This antibody is produced using advanced techniques and rigorous quality control measures to ensure optimal performance and reliability.

The p53 protein plays a crucial role in regulating cell cycle progression, DNA repair, and apoptosis. Phosphorylation of p53 at threonine 387 has been implicated in various cellular processes, including cell cycle arrest and apoptosis induction. Therefore, the ability to accurately measure the phosphorylation status of p53 at this specific site is of great importance in understanding its functional role in cellular signaling pathways.

This polyclonal antibody has been extensively validated for its specificity and sensitivity in various experimental settings, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with non-phosphorylated p53 and other related proteins, ensuring reliable and accurate results.

The p53(Phospho Thr387) Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, allowing for easy customization and optimization of experimental conditions. The antibody is also compatible with a wide range of detection systems and can be used in both research and clinical applications.

In summary, the p53(Phospho Thr387) Polyclonal Antibody is a highly reliable and specific tool for the detection and quantification of phosphorylated p53 at threonine 387. Its exceptional performance and versatility make it an invaluable asset for researchers and clinicians studying the role of p53 in various cellular processes and diseases.