p53(Phospho Thr18) Polyclonal Antibody

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277).

The p53(Phospho Thr18) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of p53 protein phosphorylated at threonine 18. This antibody is produced using advanced techniques and rigorous quality control measures to ensure optimal performance and reliability.

The p53 protein plays a crucial role in regulating cell cycle progression, DNA repair, and apoptosis. Phosphorylation of p53 at threonine 18 has been implicated in various cellular processes, including stress response, DNA damage, and tumor suppression. Therefore, the ability to accurately detect and quantify p53 phosphorylated at threonine 18 is of utmost importance in understanding the intricate mechanisms underlying these biological processes.

This polyclonal antibody exhibits exceptional specificity towards p53 phosphorylated at threonine 18, enabling precise and reliable detection in various sample types, including cell lysates, tissue extracts, and immunohistochemistry. Its high sensitivity ensures accurate quantification even in samples with low expression levels of phosphorylated p53.

Furthermore, this antibody has been extensively validated through rigorous testing, including Western blot analysis, immunoprecipitation, and immunofluorescence. Its performance has been demonstrated in a wide range of experimental settings, making it a versatile tool for researchers in the fields of cancer biology, cell signaling, and molecular biology.

In summary, the p53(Phospho Thr18) Polyclonal Antibody is a highly reliable and specific reagent that enables accurate detection and quantification of p53 protein phosphorylated at threonine 18. Its exceptional sensitivity and versatility make it an invaluable tool for researchers aiming to unravel the complex mechanisms underlying cellular processes and diseases associated with p53 signaling.