p53(Phospho Ser9) Polyclonal Antibody

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277).

The p53(Phospho Ser9) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated serine 9 residue on the p53 protein. This antibody is produced using advanced polyclonal antibody production techniques, ensuring high affinity and specificity towards the target epitope.

The p53 protein is a crucial tumor suppressor that plays a pivotal role in regulating cell cycle progression, DNA repair, and apoptosis. Phosphorylation of serine 9 on p53 has been implicated in various cellular processes, including the activation of p53-mediated transcriptional activity and the stabilization of the protein.

This polyclonal antibody has been extensively validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits exceptional sensitivity and specificity, enabling accurate and reliable detection of phosphorylated serine 9 on p53 in a wide range of sample types.

The p53(Phospho Ser9) Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and complex antibody preparation procedures. It is compatible with various detection systems and can be used in combination with other antibodies for multiplex analysis.

With its superior performance and versatility, the p53(Phospho Ser9) Polyclonal Antibody is an indispensable tool for researchers and scientists studying the intricate mechanisms of p53 signaling pathways and its involvement in cancer development and progression.