p53(Phospho Ser37) Polyclonal Antibody

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277).

The p53(Phospho Ser37) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated serine 37 residue on the p53 protein. This antibody is produced using advanced polyclonal antibody production techniques, ensuring high affinity and specificity towards the target epitope.

The p53 protein is a crucial tumor suppressor that plays a pivotal role in regulating cell cycle progression, DNA repair, and apoptosis. Phosphorylation of serine 37 residue on p53 has been implicated in various cellular processes, including the activation of p53-mediated transcriptional activity and stabilization of the protein.

This polyclonal antibody is rigorously validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits exceptional sensitivity and specificity, enabling accurate and reliable detection of phosphorylated serine 37 residue on p53 in various sample types.

The p53(Phospho Ser37) Polyclonal Antibody is manufactured using high-quality materials and state-of-the-art production techniques, ensuring consistent and reproducible results. It is supplied as a liquid formulation, ready for immediate use, and is compatible with a wide range of experimental protocols.

Researchers and scientists working in the fields of cancer biology, cell signaling, and molecular biology will greatly benefit from the use of this antibody. Its high specificity and sensitivity make it an invaluable tool for studying the role of p53 phosphorylation in various cellular processes and disease states.

In summary, the p53(Phospho Ser37) Polyclonal Antibody is a reliable and efficient tool for the detection and quantification of phosphorylated serine 37 residue on the p53 protein. Its exceptional performance and versatility make it an essential component of any research project aiming to elucidate the intricate mechanisms underlying p53-mediated cellular responses.