p53(Phospho Ser366) Polyclonal Antibody

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277).

The p53(Phospho-Ser366) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of p53 protein phosphorylated at Serine 366. This antibody is produced using advanced techniques and rigorous quality control measures to ensure optimal performance and reliability.

The p53 protein plays a crucial role in regulating cell cycle progression, DNA repair, and apoptosis. Phosphorylation of p53 at Serine 366 has been implicated in various cellular processes, including cell cycle arrest and apoptosis induction. Therefore, the ability to accurately measure the levels of p53 phosphorylated at Serine 366 is of great importance in understanding the molecular mechanisms underlying these processes.

This polyclonal antibody has been extensively validated for its specificity and sensitivity in various experimental settings, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits minimal cross-reactivity with other phosphorylated forms of p53, ensuring accurate and reliable results.

The p53(Phospho-Ser366) Polyclonal Antibody is supplied as a liquid formulation, ready to use for various applications. It is provided in a convenient size and format, allowing for easy handling and storage. The antibody is suitable for use in both research and clinical settings, enabling scientists and clinicians to investigate the role of p53 phosphorylation at Serine 366 in various diseases and conditions.

In summary, the p53(Phospho-Ser366) Polyclonal Antibody is a highly specific and sensitive tool that enables accurate detection and quantification of p53 protein phosphorylated at Serine 366. Its superior performance, reliability, and versatility make it an essential reagent for researchers and clinicians studying the intricate molecular pathways involving p53 and its phosphorylation events.