p53(Phospho Ser33) Polyclonal Antibody

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277).

The p53(Phospho Ser33) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated serine 33 residue on the p53 protein. This antibody is produced using advanced techniques and rigorous quality control measures to ensure optimal performance and reliability.

The p53 protein plays a crucial role in regulating cell cycle progression and preventing the formation of tumors. Phosphorylation of serine 33 residue on p53 has been implicated in various cellular processes, including DNA damage response and apoptosis. Therefore, the ability to accurately measure the phosphorylation status of p53 at serine 33 is of great importance in understanding the molecular mechanisms underlying these processes.

This polyclonal antibody has been extensively validated for its specificity and sensitivity in various experimental settings, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with other phosphorylated residues on p53 or unrelated proteins, ensuring reliable and accurate results.

The p53(Phospho Ser33) Polyclonal Antibody is supplied as a liquid formulation, ready to use for various applications. It is provided in a convenient size and format, allowing for easy handling and storage. The antibody is compatible with a wide range of sample types, including cell lysates, tissue extracts, and purified proteins.

With its exceptional performance and reliability, the p53(Phospho Ser33) Polyclonal Antibody is an indispensable tool for researchers and scientists studying the intricate signaling pathways involving p53 and its phosphorylation events. Its high specificity and sensitivity make it an ideal choice for both basic research and clinical applications, contributing to a better understanding of cancer biology and the development of novel therapeutic strategies.