p53(Phospho Ser20) Polyclonal Antibody

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277).

The p53(Phospho Ser20) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated serine 20 residue on the p53 protein. This antibody is produced using advanced techniques and rigorous quality control measures to ensure optimal performance and reliability.

The p53 protein plays a crucial role in regulating cell cycle progression, DNA repair, and apoptosis. Phosphorylation of serine 20 on p53 has been implicated in various cellular processes, including the activation of p53-dependent transcriptional activity and stabilization of the protein. Therefore, the detection and quantification of phosphorylated serine 20 on p53 are of great importance in understanding the functional regulation of this key tumor suppressor protein.

The p53(Phospho Ser20) Polyclonal Antibody exhibits high specificity towards phosphorylated serine 20 on p53, with minimal cross-reactivity to non-phosphorylated forms of p53 or other proteins. This antibody has been extensively validated in various experimental settings, including Western blotting, immunohistochemistry, and immunofluorescence, demonstrating its versatility and reliability.

With its superior sensitivity and specificity, the p53(Phospho Ser20) Polyclonal Antibody is an invaluable tool for researchers studying the role of p53 in cancer biology, DNA damage response, and cellular stress signaling pathways. Its application in both basic research and clinical studies holds great potential for advancing our understanding of p53-mediated cellular processes and developing novel therapeutic strategies targeting this critical protein.

Order your p53(Phospho Ser20) Polyclonal Antibody today and unlock new insights into the intricate mechanisms governing p53 function and its implications in human health and disease.