p53(Phospho Ser15) Polyclonal Antibody

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277).

The p53(Phospho Ser15) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated serine 15 residue on the p53 protein. This antibody is produced using advanced techniques and rigorous quality control measures to ensure optimal performance and reliability.

The p53 protein plays a crucial role in regulating cell cycle progression and preventing the formation of tumors. Phosphorylation of serine 15 on p53 is known to enhance its transcriptional activity and stability, making it an important target for research in cancer biology and related fields.

This polyclonal antibody has been extensively validated for its specificity and sensitivity in various experimental settings, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with non-phosphorylated p53 and other related proteins, ensuring accurate and reliable results.

With its high affinity and specificity, the p53(Phospho Ser15) Polyclonal Antibody offers researchers a valuable tool for studying the phosphorylation status of p53 and its functional implications in cellular processes. Its superior performance and consistent results make it an ideal choice for both basic research and clinical applications.

Each batch of this antibody is carefully characterized and tested to meet the highest standards of quality and performance. It is supplied in a convenient format, allowing for easy storage and handling. Furthermore, our dedicated technical support team is available to provide assistance and guidance to ensure successful implementation of this antibody in your experiments.

In summary, the p53(Phospho Ser15) Polyclonal Antibody is a reliable and efficient tool for investigating the phosphorylation status of p53 protein. Its high specificity, sensitivity, and consistent performance make it an invaluable asset for researchers in the field of cancer biology and beyond.