p53 (Mono Methyl Lys370) Polyclonal Antibody

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277).

The p53 (Mono Methyl Lys370) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of p53 protein in various biological samples. This antibody is produced using advanced techniques, ensuring high affinity and specificity towards the mono methylated form of p53 at Lysine 370 residue.

The p53 protein plays a crucial role in regulating cell cycle progression, DNA repair, and apoptosis. Dysregulation of p53 has been implicated in numerous diseases, including cancer. Therefore, accurate detection and quantification of p53 protein levels are of utmost importance in both research and clinical settings.

This polyclonal antibody has been extensively validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits excellent sensitivity and specificity, enabling reliable and reproducible results.

The p53 (Mono Methyl Lys370) Polyclonal Antibody is manufactured under strict quality control standards, ensuring batch-to-batch consistency and reliability. It is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation.

With its exceptional performance and reliability, the p53 (Mono Methyl Lys370) Polyclonal Antibody is an indispensable tool for researchers and clinicians studying p53 protein function and its involvement in various diseases, particularly cancer.