p53 (Acetyl-K305) Polyclonal Antibody

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277).

The p53 (Acetyl-K305) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of p53 protein acetylated at lysine 305. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity for the target antigen.

The p53 protein is a crucial tumor suppressor that plays a pivotal role in regulating cell cycle progression, DNA repair, and apoptosis. Acetylation of p53 at lysine 305 has been shown to modulate its transcriptional activity and stability, making it an important post-translational modification to study in the context of cancer and other diseases.

This polyclonal antibody is rigorously validated for various applications, including Western blotting, immunoprecipitation, immunofluorescence, and immunohistochemistry. It exhibits excellent performance in detecting endogenous levels of acetylated p53 in various cell and tissue types.

With its high specificity and sensitivity, the p53 (Acetyl-K305) Polyclonal Antibody is an indispensable tool for researchers studying the functional significance of p53 acetylation and its implications in disease pathogenesis. Its reliable performance and reproducibility make it an ideal choice for both basic research and clinical applications.

Order your p53 (Acetyl-K305) Polyclonal Antibody today and unlock new insights into the intricate regulatory mechanisms of p53 protein acetylation.