p53 (Acetyl-K120) Polyclonal Antibody

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277).

The p53 (Acetyl-K120) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of p53 protein acetylated at lysine 120. This antibody is produced using advanced techniques and high-quality materials to ensure optimal performance and reliability.

The p53 protein is a crucial regulator of cell cycle progression and plays a pivotal role in maintaining genomic stability. Acetylation of p53 at lysine 120 has been shown to modulate its transcriptional activity and influence various cellular processes, including DNA repair, apoptosis, and senescence. Therefore, the detection and quantification of p53 acetylated at lysine 120 are of great importance in understanding the molecular mechanisms underlying these cellular processes.

The p53 (Acetyl-K120) Polyclonal Antibody exhibits exceptional specificity and sensitivity, enabling accurate and reliable detection of acetylated p53 at lysine 120 in various sample types, including cell lysates and tissue extracts. This antibody has been extensively validated through rigorous testing, ensuring its superior performance and reproducibility.

Furthermore, the p53 (Acetyl-K120) Polyclonal Antibody is manufactured in compliance with strict quality control standards, guaranteeing its consistency and reliability. It is supplied as a liquid formulation, ready for immediate use, and is compatible with various immunological techniques, including Western blotting, immunoprecipitation, and immunofluorescence.

In summary, the p53 (Acetyl-K120) Polyclonal Antibody is a highly specific and sensitive tool that enables accurate detection and analysis of p53 protein acetylated at lysine 120. Its exceptional performance, reliability, and compatibility with various immunological techniques make it an invaluable asset for researchers studying the role of p53 acetylation in cellular processes and disease pathogenesis.