p40-phox(Phospho Thr154) Polyclonal Antibody

The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding d

The p47-phox(Phospho Ser304) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of p47-phox protein phosphorylated at Ser304. This antibody is produced using advanced techniques and high-quality materials to ensure optimal performance and reliability.

The p47-phox protein plays a crucial role in the regulation of reactive oxygen species (ROS) production by the NADPH oxidase complex. Phosphorylation of p47-phox at Ser304 has been shown to be an important post-translational modification that regulates the activation and function of the NADPH oxidase complex.

This polyclonal antibody has been extensively validated for its specificity and sensitivity in various experimental settings, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits minimal cross-reactivity with non-phosphorylated p47-phox protein, ensuring accurate and reliable results.

The p47-phox(Phospho Ser304) Polyclonal Antibody is supplied as a liquid formulation in a convenient size, allowing for easy handling and storage. It is provided in a ready-to-use format, eliminating the need for time-consuming and complex preparation steps.

With its exceptional specificity, sensitivity, and ease of use, the p47-phox(Phospho Ser304) Polyclonal Antibody is an indispensable tool for researchers studying the role of p47-phox phosphorylation in various biological processes, including inflammation, immune response, and oxidative stress.