p38(Phospho Thr180) Polyclonal Antibody

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding d

The p38(Phospho Thr180) Polyclonal Antibody is a highly specific and sensitive tool for the detection and quantification of p38 protein phosphorylated at threonine 180. This antibody is produced using a polyclonal approach, ensuring a diverse population of antibodies that can recognize multiple epitopes on the target protein.

The p38 protein is a member of the mitogen-activated protein kinase (MAPK) family and plays a crucial role in various cellular processes, including cell proliferation, differentiation, and apoptosis. Phosphorylation of p38 at threonine 180 is known to activate its kinase activity, leading to downstream signaling events.

This polyclonal antibody has been rigorously validated for its specificity and sensitivity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with other phosphorylated proteins, ensuring accurate and reliable results.

The p38(Phospho Thr180) Polyclonal Antibody is supplied as a liquid formulation, ready to use for immediate experimentation. It is provided in a convenient size and quantity, allowing for multiple experiments without the need for frequent reordering.

With its high specificity, sensitivity, and versatility, the p38(Phospho Thr180) Polyclonal Antibody is an essential tool for researchers studying the role of p38 protein phosphorylation in various biological processes.