p300(Phospho Ser89) Polyclonal Antibody

This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.

The p300(Phospho Ser89) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of p300 protein phosphorylated at Ser89. This antibody is produced using advanced techniques and rigorous quality control measures to ensure optimal performance and reliability.

The p300 protein is a transcriptional coactivator that plays a crucial role in various cellular processes, including gene expression, cell proliferation, and differentiation. Phosphorylation of p300 at Ser89 has been implicated in the regulation of its activity and function. Therefore, the p300(Phospho Ser89) Polyclonal Antibody provides a valuable tool for studying the phosphorylation status of p300 and its impact on cellular processes.

This antibody exhibits high specificity towards the phosphorylated form of p300 at Ser89, with minimal cross-reactivity to non-phosphorylated p300 or other related proteins. It has been extensively validated in various experimental settings, including Western blotting, immunoprecipitation, and immunofluorescence, ensuring its suitability for a wide range of applications.

The p300(Phospho Ser89) Polyclonal Antibody is supplied as a liquid formulation in a convenient size, allowing for easy handling and storage. It is provided in a ready-to-use format, eliminating the need for time-consuming and complex preparation steps. The antibody is also compatible with commonly used detection systems and can be used in combination with other antibodies for multiplexing experiments.

In summary, the p300(Phospho Ser89) Polyclonal Antibody is a reliable and efficient tool for investigating the phosphorylation status of p300 at Ser89. Its high specificity, sensitivity, and versatility make it an ideal choice for researchers studying the role of p300 in various biological processes.