p27(Phospho Thr198) Polyclonal Antibody

This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4).

The p27(Phospho Thr198) Polyclonal Antibody is a highly specific and sensitive tool for the detection and quantification of p27 protein phosphorylated at threonine 198. This antibody is produced using advanced techniques and high-quality materials to ensure optimal performance and reliability.

The p27 protein plays a crucial role in cell cycle regulation and acts as a tumor suppressor. Phosphorylation of p27 at threonine 198 has been implicated in various cellular processes, including cell proliferation, differentiation, and apoptosis. Therefore, the ability to accurately measure the levels of p27 phosphorylated at this specific site is essential for understanding its functional significance in various biological contexts.

This polyclonal antibody has been extensively validated for its specificity and sensitivity in various experimental settings, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with other phosphorylated proteins, ensuring accurate and reliable results.

The p27(Phospho Thr198) Polyclonal Antibody is supplied as a liquid formulation in a convenient size, allowing for easy handling and storage. It is provided in a ready-to-use format, eliminating the need for time-consuming and error-prone antibody preparation steps.

With its exceptional performance characteristics and broad applicability, the p27(Phospho Thr198) Polyclonal Antibody is an indispensable tool for researchers studying cell cycle regulation, tumor biology, and related fields. Its high specificity, sensitivity, and reliability make it an ideal choice for accurate and reproducible detection and quantification of p27 phosphorylated at threonine 198.