p27(Phospho Thr157) Polyclonal Antibody

This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4).

The p27(Phospho Thr157) Polyclonal Antibody is a highly specific and sensitive tool for the detection and quantification of p27 protein phosphorylated at threonine 157. This antibody has been rigorously validated for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The p27 protein plays a crucial role in cell cycle regulation and acts as a tumor suppressor. Phosphorylation of p27 at threonine 157 has been implicated in the modulation of its stability and subcellular localization, thereby influencing its function in cell cycle progression and cell proliferation.

This polyclonal antibody has been developed using state-of-the-art techniques and exhibits exceptional specificity towards the phosphorylated form of p27 at threonine 157. It has been extensively tested and validated to ensure reliable and reproducible results.

The p27(Phospho Thr157) Polyclonal Antibody offers several advantages over other antibodies available in the market. It exhibits minimal cross-reactivity with non-phosphorylated p27 and other related proteins, ensuring accurate and specific detection. Additionally, it demonstrates high sensitivity, allowing for the detection of low levels of phosphorylated p27 in various sample types.

This antibody is supplied as a liquid formulation, making it easy to handle and use. It is provided in a convenient size and concentration, allowing for multiple experiments and minimizing wastage. The antibody has been optimized for use in various experimental conditions and can be used with confidence in a wide range of research applications.

In summary, the p27(Phospho Thr157) Polyclonal Antibody is a reliable and versatile tool for the detection and quantification of phosphorylated p27 protein at threonine 157. Its exceptional specificity, sensitivity, and ease of use make it an ideal choice for researchers studying cell cycle regulation, tumor suppression, and related fields.