p27(Phospho Ser178) Polyclonal Antibody

This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4).

The p27(Phospho Ser178) Polyclonal Antibody is a highly specific and sensitive tool for the detection and quantification of p27 protein phosphorylated at Ser178. This antibody has been rigorously validated for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The p27 protein plays a crucial role in cell cycle regulation and acts as a tumor suppressor. Phosphorylation of p27 at Ser178 has been implicated in the modulation of its stability and subcellular localization, thereby affecting its function in cell cycle progression and cell proliferation.

Our p27(Phospho Ser178) Polyclonal Antibody has been meticulously developed using state-of-the-art techniques to ensure high specificity and sensitivity. It has been extensively tested and validated to provide reliable and reproducible results.

This antibody exhibits exceptional performance in Western blotting, enabling the detection of p27 protein phosphorylated at Ser178 with high sensitivity and minimal background. It also demonstrates excellent performance in immunohistochemistry, allowing for the visualization and localization of p27 protein phosphorylated at Ser178 in tissue samples.

Furthermore, the p27(Phospho Ser178) Polyclonal Antibody is compatible with various secondary detection systems, making it versatile and adaptable to different experimental setups.

In summary, the p27(Phospho Ser178) Polyclonal Antibody is a valuable tool for researchers studying cell cycle regulation, tumor suppression, and cell proliferation. Its high specificity, sensitivity, and versatility make it an essential component of any laboratory involved in these fields of research.