p27(Phospho Ser10) Polyclonal Antibody

This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4).

The p27(Phospho Ser10) Polyclonal Antibody is a highly specific and sensitive tool for the detection and quantification of p27 protein phosphorylated at Ser10. This antibody has been rigorously validated and exhibits exceptional performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The p27 protein plays a crucial role in cell cycle regulation and acts as a tumor suppressor. Phosphorylation of p27 at Ser10 has been implicated in various cellular processes, including cell proliferation, differentiation, and apoptosis. Therefore, the ability to accurately measure the levels of p27 phosphorylated at Ser10 is of utmost importance in understanding the underlying mechanisms of these processes.

Our p27(Phospho Ser10) Polyclonal Antibody has been developed using state-of-the-art techniques and high-quality materials to ensure optimal performance and reliability. It exhibits high specificity towards p27 phosphorylated at Ser10, with minimal cross-reactivity to non-phosphorylated p27 or other proteins.

This antibody has been extensively tested and validated using a variety of cell lines and tissue samples. It consistently demonstrates strong and specific staining patterns, allowing for precise localization and quantification of p27 phosphorylated at Ser10. Its exceptional sensitivity enables the detection of low-abundance targets, making it an invaluable tool for researchers studying p27 signaling pathways and its involvement in various diseases, including cancer.

The p27(Phospho Ser10) Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and format, allowing for easy handling and storage. Each batch is quality controlled to ensure consistent performance and reliability.

In summary, the p27(Phospho Ser10) Polyclonal Antibody is a highly specific and sensitive tool for the detection and quantification of p27 protein phosphorylated at Ser10. Its exceptional performance in various applications, combined with its reliability and convenience, makes it an ideal choice for researchers in the field of cell biology and cancer research.