p21(Phospho Thr145) Polyclonal Antibody

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lac

The p21(Phospho Thr145) Polyclonal Antibody is a highly specific and sensitive tool for the detection and quantification of p21 protein phosphorylated at threonine 145. This antibody has been rigorously validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The p21 protein, also known as cyclin-dependent kinase inhibitor 1, plays a crucial role in cell cycle regulation and is involved in the control of cell proliferation and differentiation. Phosphorylation of p21 at threonine 145 has been shown to modulate its stability and activity, making it an important post-translational modification to study.

Our p21(Phospho Thr145) Polyclonal Antibody has been carefully developed and optimized to ensure high specificity and sensitivity. It has been extensively tested against a wide range of samples, including human, mouse, and rat tissues, to ensure reliable and reproducible results.

This antibody offers several advantages over other commercially available antibodies. It exhibits minimal cross-reactivity with non-phosphorylated p21 protein, ensuring accurate detection of the phosphorylated form. Additionally, it demonstrates excellent signal-to-noise ratio and low background, enabling clear and precise visualization of p21(Phospho Thr145) in complex biological samples.

The p21(Phospho Thr145) Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody dilution. It is provided in a convenient size, allowing for multiple experiments without the risk of antibody degradation.

In summary, the p21(Phospho Thr145) Polyclonal Antibody is a reliable and efficient tool for the detection and quantification of phosphorylated p21 protein. Its high specificity, sensitivity, and ease of use make it an ideal choice for researchers studying cell cycle regulation, cancer biology, and other related fields.