NPHP1 Polyclonal Antibody

This gene encodes a protein with src homology domain 3 (SH3) patterns. This protein interacts with Crk-associated substrate, and it appears to function in the control of cell division, as well as in cell-cell and cell-matrix adhesion signaling, likely as part of a multifunctional complex localized in actin- and microtubule-based structures. Mutations in this gene cause familial juvenile nephronophthisis type 1, a kidney disorder involving both tubules and glomeruli. Defects in this gene are also associated with Senior-Loken syndrome type 1, also referred to as juvenile nephronophthisis with Leber amaurosis, which is characterized by kidney and eye disease, and with Joubert syndrome type 4, which is characterized by cerebellar ataxia, oculomotor apraxia, psychomotor delay and neonatal breathing abnormalities, sometimes including retinal dystrophy and renal disease. Multiple transcript variants encoding diffe

The NPHP1 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of NPHP1 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the N-terminal region of human NPHP1 protein. The antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The NPHP1 Polyclonal Antibody is a valuable tool for researchers studying the role of NPHP1 protein in various biological processes, including ciliopathies, renal diseases, and retinal degeneration. This antibody can be used to detect NPHP1 protein expression in various tissues and cell types, including kidney, retina, and brain. The antibody has been shown to detect endogenous NPHP1 protein in human and mouse tissues, as well as in cultured cells.

The NPHP1 Polyclonal Antibody is supplied as a purified IgG fraction, which has been affinity-purified using a protein A column. The antibody is provided in a liquid form, which can be easily diluted in various buffers for use in different applications. The antibody has been tested for its stability and can be stored at -20°C for long-term storage.

In summary, the NPHP1 Polyclonal Antibody is a highly specific and sensitive antibody that can be used for the detection of NPHP1 protein in various biological samples. This antibody is a valuable tool for researchers studying the role of NPHP1 protein in various biological processes and diseases.