Noggin Polyclonal Antibody

The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and mu

The Noggin Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of Noggin protein in various biological samples. This antibody is produced using a polyclonal approach, ensuring a diverse range of antibodies that recognize different epitopes of the target protein.

The Noggin Polyclonal Antibody has been rigorously validated for its specificity and sensitivity through various experimental techniques, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with other related proteins, ensuring accurate and reliable results.

This antibody is manufactured using state-of-the-art techniques and undergoes stringent quality control measures to ensure batch-to-batch consistency and reproducibility. It is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation.

The Noggin Polyclonal Antibody is suitable for a wide range of applications, including basic research, drug discovery, and clinical diagnostics. It can be used in various sample types, such as cell lysates, tissue homogenates, and serum/plasma. Its high sensitivity allows for the detection of low-abundance Noggin protein, enabling researchers to study its role in various biological processes.

In summary, the Noggin Polyclonal Antibody is a reliable and versatile tool for the detection and quantification of Noggin protein. Its high specificity, sensitivity, and ease of use make it an essential component of any research or diagnostic laboratory.