NIPBL Polyclonal Antibody

This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and mental retardation. Two transcript variants encoding different isoforms have been found for this gene.

 

The NIPBL Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of NIPBL protein expression in various biological samples. This antibody has been meticulously developed using advanced immunization techniques and exhibits exceptional sensitivity and specificity towards NIPBL protein.

The NIPBL Polyclonal Antibody is produced by immunizing rabbits with a synthetic peptide corresponding to a specific region of the NIPBL protein. This rigorous immunization process ensures the generation of high-affinity antibodies that specifically recognize the target protein. The resulting antibody is purified using a combination of affinity chromatography and protein A/G purification methods, guaranteeing a high-quality product with minimal background noise.

This antibody has been extensively validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has demonstrated excellent sensitivity and specificity in detecting endogenous NIPBL protein in a wide range of cell lines and tissues. The NIPBL Polyclonal Antibody is suitable for both qualitative and quantitative analysis of NIPBL protein expression.

With its exceptional performance and reliability, the NIPBL Polyclonal Antibody is an indispensable tool for researchers studying the role of NIPBL protein in various biological processes. Its high specificity and sensitivity make it an ideal choice for investigating NIPBL protein expression levels, localization, and interactions in both normal and disease conditions.

In summary, the NIPBL Polyclonal Antibody is a superior research tool that offers reliable and accurate detection of NIPBL protein. Its exceptional performance, combined with its versatility in various applications, makes it an essential asset for researchers in the field of molecular biology, genetics, and developmental biology.