Neu(Phospho Tyr877) Polyclonal Antibody

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding d

 The Neu(Phospho Tyr877) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of Neu protein phosphorylated at tyrosine 877. This antibody is produced using advanced immunization techniques, resulting in a high affinity and specificity towards the phosphorylated form of Neu.

The Neu protein, also known as ErbB2 or HER2, is a receptor tyrosine kinase that plays a crucial role in cell growth, differentiation, and survival. Dysregulation of Neu signaling has been implicated in various cancers, making it an important target for therapeutic interventions.

The phosphorylation of Neu at tyrosine 877 is a critical event in the activation of downstream signaling pathways, leading to cell proliferation and survival. The Neu(Phospho Tyr877) Polyclonal Antibody recognizes and binds specifically to the phosphorylated form of Neu, enabling the study of its activation status in various biological samples.

This antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunoprecipitation, and immunohistochemistry. It exhibits minimal cross-reactivity with non-phosphorylated Neu and other related proteins, ensuring accurate and reliable results.

The Neu(Phospho Tyr877) Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, allowing for easy customization and optimization of experimental conditions. Each batch of antibody undergoes rigorous quality control testing to ensure consistent performance and reproducibility.

In summary, the Neu(Phospho Tyr877) Polyclonal Antibody is a valuable tool for researchers studying the activation and signaling pathways of Neu protein. Its high specificity, sensitivity, and versatility make it an ideal choice for a wide range of applications in cancer research and drug development.