Neu(Phospho Tyr1248) Polyclonal Antibody

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding d

The Neu(Phospho Tyr1248) Polyclonal Antibody is a highly specific and sensitive tool for the detection and analysis of Neu protein phosphorylated at Tyr1248. This antibody has been rigorously validated for use in various applications, including Western blotting, immunoprecipitation, and immunohistochemistry.

The Neu protein, also known as ErbB2 or HER2, is a receptor tyrosine kinase that plays a crucial role in cell growth, differentiation, and survival. Phosphorylation of Tyr1248 is a key event in the activation of Neu signaling pathways, leading to the activation of downstream signaling molecules and the promotion of cell proliferation.

Our Neu(Phospho Tyr1248) Polyclonal Antibody has been developed using state-of-the-art techniques and high-quality materials to ensure optimal performance and reliability. It exhibits exceptional specificity, binding only to the phosphorylated form of Neu at Tyr1248, while showing minimal cross-reactivity with non-phosphorylated Neu or other related proteins.

This antibody has been extensively tested and validated using a variety of cell lines and tissues, demonstrating its robustness and accuracy. It provides clear and reliable results, enabling researchers to confidently investigate the role of Neu phosphorylation in various biological processes and disease states.

The Neu(Phospho Tyr1248) Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and format, allowing for easy handling and storage. Each batch is subjected to rigorous quality control procedures to ensure consistency and reproducibility.

In summary, the Neu(Phospho Tyr1248) Polyclonal Antibody is a highly reliable and specific tool for the detection and analysis of Neu protein phosphorylated at Tyr1248. Its exceptional performance and versatility make it an invaluable asset for researchers studying the role of Neu signaling in various biological processes and disease states.