NDUV1 Polyclonal Antibody

The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V). This gene encodes a 51 kDa subunit of the NADH:ubiquinone oxidoreductase complex I; a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone. This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN)- and Fe-S-biding sites. Defects in complex I are a common cause of mitochondrial dysfunction; a syndrome that occurs in approximately 1 in 10,000 live births. Mitochondrial complex I deficiency is linked to myopathies, encephalomyopathies, and neurodegenerative disorders such as Parkinson's disease and Leigh syndrome. Alternative splicing results in multiple trans

The Neu(Phospho Tyr1112) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Neu protein phosphorylated at Tyr1112. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards the target antigen.

The Neu protein, also known as ErbB2 or HER2, is a member of the epidermal growth factor receptor (EGFR) family. It plays a crucial role in cell growth, differentiation, and survival. Dysregulation of Neu signaling has been implicated in various cancers, making it an important target for therapeutic interventions.

The phosphorylation of Neu at Tyr1112 is a critical event in its activation and downstream signaling pathways. The Neu(Phospho Tyr1112) Polyclonal Antibody recognizes and binds specifically to the phosphorylated form of Neu at this site, enabling the detection and quantification of activated Neu in various biological samples.

This antibody has been extensively validated for its performance in various applications, including Western blotting, immunoprecipitation, immunofluorescence, and immunohistochemistry. It exhibits excellent sensitivity and specificity, allowing for accurate and reliable results.

The Neu(Phospho Tyr1112) Polyclonal Antibody is supplied as a liquid formulation, ready to use for laboratory research purposes. It is provided in a convenient size and quantity, ensuring cost-effectiveness and minimizing wastage.

In summary, the Neu(Phospho Tyr1112) Polyclonal Antibody is a valuable tool for researchers studying the role of Neu signaling in cancer and other diseases. Its high specificity, sensitivity, and versatility make it an essential component of any laboratory involved in the investigation of Neu protein function and regulation.