MRE11(Phospho Ser264) Polyclonal Antibody

This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

The MRE11(Phospho Ser264) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of MRE11 protein phosphorylated at Serine 264. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target protein.

MRE11 is a crucial component of the MRN complex, which plays a vital role in DNA repair and maintenance of genomic stability. Phosphorylation of MRE11 at Serine 264 has been implicated in various cellular processes, including DNA damage response and cell cycle regulation. Therefore, the ability to accurately detect and measure the phosphorylation status of MRE11 at this specific site is of utmost importance in understanding the underlying mechanisms of these processes.

The MRE11(Phospho Ser264) Polyclonal Antibody exhibits exceptional performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been extensively validated for its specificity and sensitivity, ensuring reliable and reproducible results. This antibody demonstrates minimal cross-reactivity with non-phosphorylated MRE11 and other related proteins, further enhancing its specificity.

With its high-quality formulation and optimized protocols, the MRE11(Phospho Ser264) Polyclonal Antibody offers researchers a valuable tool for investigating the role of MRE11 phosphorylation in cellular processes. Its superior performance and reliability make it an ideal choice for both basic research and clinical applications.

Order your MRE11(Phospho Ser264) Polyclonal Antibody today and unlock new insights into the intricate mechanisms of DNA repair and genomic stability.