MOR-1(Phospho Ser375) Polyclonal Antibody

This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains.

The MOR-1(Phospho Ser375) Polyclonal Antibody is a highly specific and sensitive tool for the detection and quantification of phosphorylated Ser375 in the MOR-1 protein. This antibody has been rigorously validated and exhibits exceptional performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The MOR-1 protein, also known as the mu-opioid receptor, plays a crucial role in mediating the effects of opioids in the central nervous system. Phosphorylation of Ser375 has been implicated in the regulation of MOR-1 signaling and function. Therefore, the ability to accurately measure the phosphorylation status of Ser375 is of great importance in understanding the molecular mechanisms underlying opioid action.

The MOR-1(Phospho Ser375) Polyclonal Antibody has been developed using state-of-the-art techniques and exhibits high specificity towards the phosphorylated form of Ser375 in the MOR-1 protein. It has been extensively validated using both synthetic peptides and cell lysates, ensuring reliable and reproducible results.

This antibody demonstrates exceptional sensitivity, allowing for the detection of low levels of phosphorylated Ser375 in complex biological samples. Its high affinity and specificity minimize the risk of cross-reactivity with other proteins, ensuring accurate and reliable quantification.

The MOR-1(Phospho Ser375) Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation. It is provided in a convenient format, allowing for easy storage and handling.

In summary, the MOR-1(Phospho Ser375) Polyclonal Antibody is a highly reliable and sensitive tool for the detection and quantification of phosphorylated Ser375 in the MOR-1 protein. Its exceptional performance and ease of use make it an invaluable asset for researchers studying the molecular mechanisms of opioid action.