MLKL(Phospho S358) Polyclonal Antibody

This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.

The MLKL(Phospho S358) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of MLKL protein phosphorylated at serine 358. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target protein.

MLKL, also known as mixed lineage kinase domain-like protein, plays a crucial role in programmed necrosis, a form of cell death. Phosphorylation of MLKL at serine 358 is a key event in the activation of necroptosis, a regulated form of necrosis. Therefore, the detection and analysis of MLKL phosphorylation at this specific site is of great importance in understanding the molecular mechanisms underlying necroptosis.

The MLKL(Phospho S358) Polyclonal Antibody has been rigorously validated for its performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits exceptional sensitivity and specificity, enabling accurate and reliable detection of phosphorylated MLKL in complex biological samples.

This antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, allowing for multiple experiments without the need for frequent reordering. The MLKL(Phospho S358) Polyclonal Antibody is manufactured under strict quality control standards, ensuring consistent and reproducible results.

In summary, the MLKL(Phospho S358) Polyclonal Antibody is a valuable tool for researchers studying necroptosis and its associated signaling pathways. Its high specificity, sensitivity, and versatility make it an essential component in the investigation of MLKL phosphorylation and its functional implications.