MICA Polyclonal Antibody

This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants.

The MICA Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of MICA protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human MICA protein. The resulting polyclonal antibody exhibits high affinity and specificity towards MICA protein, making it an ideal tool for various applications in research and diagnostics.

The MICA Polyclonal Antibody has been extensively validated for its performance in various immunoassays, including Western blotting, ELISA, immunohistochemistry, and flow cytometry. It has been shown to detect MICA protein in a wide range of sample types, including cell lysates, tissue homogenates, serum, plasma, and other biological fluids. The antibody has also been tested for its cross-reactivity with other related proteins and has been found to be highly specific for MICA protein.

The MICA Polyclonal Antibody is supplied as a purified IgG fraction, which has been affinity-purified from rabbit serum using protein A chromatography. The antibody is provided in a liquid form, which can be easily diluted and used in various immunoassays. It is recommended to store the antibody at -20°C in aliquots to avoid repeated freeze-thaw cycles.

In summary, the MICA Polyclonal Antibody is a highly specific and sensitive immunological reagent that can be used for the detection and quantification of MICA protein in various biological samples. Its high affinity and specificity make it an ideal tool for various applications in research and diagnostics.