MIB2 Polyclonal Antibody

E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.,induction:Down-regulated in many primary skin melanomas. Treatment with a demethylating agent, 5'-aza-2-deoxycytidine, restores expression, suggesting that down-regulation is the result of methylation of the gene.,pathway:Protein modification; protein ubiquitination.,PTM:Ubiquitinated. Possibly via autoubiquitination.,Contains 1 ZZ-type zinc finger.,Contains 2 MIB/HERC2 domains.,Contains 2 RING-type zinc fingers.,Contains 9 ANK repeats.,subcellular location:Colocalizes with endosomal compartments.,subunit:Interacts with actin monomer.,tissue specificity:Expressed in skeletal muscle, and to a lesser extent in heart, brain and kidney.,

The MIB2 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of MIB2 protein expression in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards the target protein.

The MIB2 Polyclonal Antibody exhibits exceptional performance in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It enables researchers to accurately quantify and visualize MIB2 protein levels in tissues, cells, and other biological specimens.

With its superior sensitivity, this antibody allows for the detection of low-abundance MIB2 protein, making it an invaluable tool for studying the role of MIB2 in various cellular processes and disease mechanisms. Its robust performance ensures reliable and reproducible results, facilitating meaningful scientific discoveries.

The MIB2 Polyclonal Antibody is manufactured under stringent quality control measures to ensure batch-to-batch consistency and reliability. It is supplied in a convenient and ready-to-use format, eliminating the need for time-consuming and complex preparation steps.

In summary, the MIB2 Polyclonal Antibody is a highly reliable and efficient tool for researchers seeking to investigate the expression and function of MIB2 protein. Its exceptional sensitivity, specificity, and ease of use make it an indispensable asset in various research fields, including cancer biology, developmental biology, and molecular biology.