MIA3 Polyclonal Antibody

Although 2 transmembrane domains are predicted, PubMed:19269366 showed that it only contains one transmembrane domain. The other predicted transmembrane region is probably a hairpin-type region embedded into the membrane, which does not cross the membrane. It is unclear which of the 2 predicted transmembrane regions is the transmembrane or the hairpin-type region.,The proline-rich region (PRD) mediates the interaction with COPII coat subunits Sec23/24.,Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. May participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1.,Belongs to the MIA/OTOR family. Tango1 subfamily.,Contains 1 SH3 domain.,subcellular location:Localizes at endoplasmic reticulum exit sites. After loading of COL7A1 into transport carriers, it is not incorporated into COPII carriers and remains in the endoplasmic reticulum membrane.,subunit:Interacts (via SH3 domain) with COL7A1. Associates with the COPII coat subunits Sec23/Sec24.,tissue specificity:Broadly expressed, except in bone marrow and peripheral blood mononuclear cells. Down-regulated in melanoma tissue.,

The MIA3 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of MIA3 protein expression in various biological samples. This antibody is produced using advanced techniques and rigorous quality control measures to ensure optimal performance and reliability.

The MIA3 Polyclonal Antibody exhibits exceptional affinity and specificity towards the MIA3 protein, enabling accurate and precise detection in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been extensively validated and proven to deliver consistent and reproducible results.

With its superior sensitivity, the MIA3 Polyclonal Antibody allows for the detection of low abundance MIA3 protein levels, making it an ideal choice for researchers working with limited sample quantities or challenging experimental conditions. Its robust performance ensures reliable and accurate data interpretation, facilitating meaningful insights into the role of MIA3 in various biological processes.

The MIA3 Polyclonal Antibody is supplied in a convenient and user-friendly format, allowing for easy handling and storage. It is provided in a liquid form, eliminating the need for reconstitution, and is compatible with a variety of commonly used buffers and diluents. Its long shelf life ensures consistent performance over an extended period, minimizing the need for frequent reordering.

In summary, the MIA3 Polyclonal Antibody is a highly reliable and efficient tool for the detection and analysis of MIA3 protein expression. Its exceptional sensitivity, specificity, and ease of use make it an invaluable asset for researchers in the field of molecular biology, immunology, and related disciplines.