Met(Phospho Tyr1349) Polyclonal Antibody

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers.

The Met(Phospho Tyr1349) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Met protein phosphorylated at tyrosine 1349. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards the phosphorylated form of Met.

The Met protein, also known as hepatocyte growth factor receptor (HGFR), plays a crucial role in various cellular processes, including cell growth, survival, and migration. Phosphorylation of Met at tyrosine 1349 is a key event in the activation of downstream signaling pathways, leading to the regulation of cell proliferation and differentiation.

This polyclonal antibody has been extensively validated for its performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits excellent sensitivity and specificity, enabling accurate detection and quantification of Met phosphorylated at tyrosine 1349 in various biological samples.

The Met(Phospho Tyr1349) Polyclonal Antibody is supplied as a liquid formulation, ready to use for immediate experimentation. It is provided in a convenient size, ensuring cost-effectiveness and minimizing wastage. The antibody is compatible with a wide range of experimental conditions and can be used in both research and clinical settings.

In summary, the Met(Phospho Tyr1349) Polyclonal Antibody is a reliable and efficient tool for the investigation of Met protein phosphorylation at tyrosine 1349. Its high specificity, sensitivity, and versatility make it an essential component in studies related to Met signaling pathways and associated cellular processes.