MEK-4(Phospho Thr261) Polyclonal Antibody

This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants.

The MEK-4(Phospho Thr261) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of MEK-4 protein phosphorylated at Thr261 residue. This antibody is produced using advanced polyclonal antibody production techniques, ensuring high affinity and specificity towards the target protein.

MEK-4, also known as MAP2K4, is a crucial component of the mitogen-activated protein kinase (MAPK) signaling pathway. It plays a pivotal role in regulating various cellular processes, including cell proliferation, differentiation, and apoptosis. Phosphorylation of MEK-4 at Thr261 residue is known to modulate its activity and downstream signaling events.

The MEK-4(Phospho Thr261) Polyclonal Antibody has been rigorously validated for its specificity and sensitivity through various experimental approaches, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits minimal cross-reactivity with non-phosphorylated MEK-4 and other related proteins, ensuring accurate and reliable results.

This antibody is supplied as a liquid formulation, ready for immediate use in various applications, including protein expression analysis, pathway studies, and drug discovery research. It is compatible with multiple detection methods, such as chemiluminescence, fluorescence, and colorimetric assays.

With its exceptional performance and reliability, the MEK-4(Phospho Thr261) Polyclonal Antibody is an indispensable tool for researchers and scientists working in the field of signal transduction and cellular signaling pathways. Its high specificity and sensitivity make it an ideal choice for studying the role of MEK-4 phosphorylation in various physiological and pathological conditions.