MDMX(Phospho Ser367) Polyclonal Antibody

This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

The MDMX(Phospho Ser367) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of MDMX protein phosphorylated at Serine 367. This antibody is produced using advanced techniques to ensure high affinity and specificity, making it an ideal choice for researchers studying the role of MDMX in various cellular processes.

The MDMX protein, also known as MDM4, is a critical regulator of the p53 tumor suppressor pathway. It acts as a negative regulator of p53 by binding to and inhibiting its transcriptional activity. Phosphorylation of MDMX at Serine 367 has been shown to modulate its interaction with p53, leading to altered p53 activity and downstream signaling.

This polyclonal antibody has been extensively validated for its specificity and sensitivity in various experimental settings, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits minimal cross-reactivity with other proteins, ensuring accurate and reliable results.

The MDMX(Phospho Ser367) Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size to accommodate different experimental needs. The antibody has been rigorously quality tested to ensure consistent performance and batch-to-batch reproducibility.

In summary, the MDMX(Phospho Ser367) Polyclonal Antibody is a valuable tool for researchers investigating the intricate mechanisms of the p53 pathway. Its high specificity, sensitivity, and reliability make it an indispensable asset in the quest for a deeper understanding of MDMX function and its implications in cancer and other diseases.