MARK1/2/3/4(Phospho Thr215) Polyclonal Antibody

Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-215 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39.,May play a role in cytoskeletal stability.,Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. MARK subfamily.,Contains 1 KA1 (kinase-associated) domain.,Contains 1 protein kinase domain.,Contains 1 UBA domain.,subcellular location:Appears to localize to an intracellular network.,tissue specificity:Highly expressed in heart, skeletal muscle, brain, fetal brain and fetal kidney.,

The MARK1/2/3/4(Phospho Thr215) Polyclonal Antibody is a highly specific and sensitive tool for the detection and quantification of phosphorylated threonine 215 residues in the MARK1, MARK2, MARK3, and MARK4 proteins. This antibody has been rigorously validated for its specificity and performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The phosphorylation of threonine 215 is a critical post-translational modification that regulates the activity and function of the MARK1, MARK2, MARK3, and MARK4 proteins. By targeting this specific phosphorylation site, the MARK1/2/3/4(Phospho Thr215) Polyclonal Antibody enables researchers to investigate the role of these proteins in various cellular processes, such as cell cycle regulation, neuronal development, and synaptic plasticity.

This polyclonal antibody has been developed using high-quality immunogens and advanced immunization techniques, ensuring its high affinity and specificity towards the phosphorylated threonine 215 residues. It exhibits minimal cross-reactivity with non-phosphorylated forms of the MARK1, MARK2, MARK3, and MARK4 proteins, ensuring accurate and reliable results.

The MARK1/2/3/4(Phospho Thr215) Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It has been optimized for use in various experimental conditions, including different sample types, species, and dilutions. Its versatility and robustness make it an ideal choice for researchers studying the MARK1, MARK2, MARK3, and MARK4 proteins and their phosphorylation status.

In summary, the MARK1/2/3/4(Phospho Thr215) Polyclonal Antibody is a highly specific and sensitive tool for the detection and quantification of phosphorylated threonine 215 residues in the MARK1, MARK2, MARK3, and MARK4 proteins. Its high affinity, specificity, and versatility make it an essential reagent for researchers investigating the role of these proteins in various cellular processes.