LIMK-2(Phospho Ser283) Polyclonal Antibody

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene.

The LIMK-2(Phospho Ser283) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of LIMK-2 protein phosphorylated at Serine 283. This antibody is produced using state-of-the-art techniques, ensuring high affinity and specificity for the target protein.

LIMK-2, also known as LIM domain kinase 2, plays a crucial role in regulating actin cytoskeleton dynamics and cell motility. Phosphorylation of LIMK-2 at Serine 283 has been implicated in various cellular processes, including cell migration, invasion, and metastasis. Therefore, the ability to accurately measure the phosphorylation status of LIMK-2 at this specific site is of great importance in understanding its functional significance.

The LIMK-2(Phospho Ser283) Polyclonal Antibody exhibits exceptional performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been extensively validated using a wide range of cell lines and tissues, ensuring reliable and reproducible results.

With its high specificity and sensitivity, this antibody enables researchers to investigate the role of LIMK-2 phosphorylation in various biological processes and disease states. Its superior performance and reliability make it an indispensable tool for scientists working in the fields of cell biology, cancer research, and drug discovery.

Order the LIMK-2(Phospho Ser283) Polyclonal Antibody today and unlock new insights into the intricate mechanisms governing cellular dynamics and disease progression.