LIMK-1(Phospho Thr508) Polyclonal Antibody

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cog

The LIMK-1(Phospho Thr508) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of LIMK-1 protein phosphorylated at threonine 508 residue. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target protein.

LIMK-1, also known as LIM domain kinase 1, plays a crucial role in regulating actin cytoskeleton dynamics and cell motility. Phosphorylation of LIMK-1 at threonine 508 residue is known to modulate its activity and function. Therefore, the LIMK-1(Phospho Thr508) Polyclonal Antibody serves as an invaluable tool for studying the phosphorylation status and functional implications of LIMK-1 in various biological processes.

This antibody has been extensively validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits exceptional sensitivity and specificity, enabling accurate and reliable detection of phosphorylated LIMK-1 in complex biological samples.

The LIMK-1(Phospho Thr508) Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, ensuring cost-effectiveness and minimal wastage. The antibody is also compatible with a wide range of secondary detection systems, facilitating seamless integration into existing experimental protocols.

In summary, the LIMK-1(Phospho Thr508) Polyclonal Antibody is a highly reliable and efficient tool for investigating the phosphorylation status and functional implications of LIMK-1 in various biological processes. Its exceptional sensitivity, specificity, and compatibility make it an indispensable asset for researchers in the field of cell biology, molecular biology, and related disciplines.