LEF-1(Phospho Ser42) Polyclonal Antibody

This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants.

The LEF-1(Phospho Ser42) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of LEF-1 protein phosphorylated at Ser42. This antibody has been rigorously validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The LEF-1 protein plays a crucial role in the regulation of gene expression and is involved in various cellular processes, such as cell proliferation, differentiation, and development. Phosphorylation of LEF-1 at Ser42 has been shown to modulate its transcriptional activity and influence downstream signaling pathways.

This polyclonal antibody has been meticulously developed using state-of-the-art techniques to ensure high specificity and sensitivity. It has been extensively tested and validated to provide reliable and reproducible results. The antibody exhibits minimal cross-reactivity with non-phosphorylated LEF-1 and other related proteins, ensuring accurate detection and quantification of phosphorylated LEF-1 at Ser42.

The LEF-1(Phospho Ser42) Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, allowing for easy handling and storage. The antibody is suitable for use in various experimental settings, including basic research, drug discovery, and clinical diagnostics.

In summary, the LEF-1(Phospho Ser42) Polyclonal Antibody is a reliable and versatile tool for the detection and quantification of phosphorylated LEF-1 protein at Ser42. Its high specificity, sensitivity, and validated performance make it an essential reagent for researchers and scientists working in the field of cellular signaling and gene regulation.