Lck BP-1(Phospho Tyr397) Polyclonal Antibody

developmental stage:Expressed in early stage of myeloid and erythroid differentiation.,Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.,PTM:Phosphorylated by LYN; rapidly after cross-linking of surface IgM on B-cells.,Contains 1 SH3 domain.,Contains 4 cortactin repeats.,subunit:Associates with the SH2 and SH3 domains of LCK. Binding to he LCK SH3 domain occurs constitutively, while binding to the LCK SH2 domain occurs only upon TCR stimulation. A similar binding pattern was observed with LYN, but not with FYN in which the FYN SH2 region associates upon TCR stimulation but the FYN SH3 region does not associate regardless of TCR stimulation. Directly associates with HAX1, through binding to its C-terminal region. Interacts with HS1BP3.,tissue specificity:Expressed only in tissues and cells of hematopoietic origin.,

The Lck BP-1(Phospho Tyr397) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Lck protein phosphorylated at Tyr397. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity for the target protein.

Lck, also known as lymphocyte-specific protein tyrosine kinase, plays a crucial role in T-cell development and activation. Phosphorylation of Lck at Tyr397 is a key event in the regulation of its activity and downstream signaling pathways. The Lck BP-1(Phospho Tyr397) Polyclonal Antibody enables researchers to investigate the phosphorylation status of Lck and its functional implications in various cellular processes.

This antibody has been rigorously validated for its performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits excellent sensitivity and specificity, allowing for accurate and reliable detection of phosphorylated Lck in complex biological samples.

The Lck BP-1(Phospho Tyr397) Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, ensuring cost-effectiveness and minimizing waste. The antibody is compatible with a wide range of experimental conditions and can be used in both basic research and clinical applications.

In summary, the Lck BP-1(Phospho Tyr397) Polyclonal Antibody is a valuable tool for researchers studying Lck signaling pathways and its role in T-cell biology. Its high specificity, sensitivity, and versatility make it an essential component of any laboratory investigating protein phosphorylation events.