Lck(Phospho Tyr192) Polyclonal Antibody

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described.

The Lck(Phospho Tyr192) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Lck protein phosphorylated at tyrosine 192. This antibody is produced using a polyclonal approach, ensuring a high affinity and specificity towards the target protein.

Lck, also known as lymphocyte-specific protein tyrosine kinase, plays a crucial role in T-cell development and activation. Phosphorylation of Lck at tyrosine 192 is a key event in the regulation of its activity and downstream signaling pathways. Therefore, the ability to detect and quantify this phosphorylation event is of great importance in understanding the molecular mechanisms underlying T-cell function.

The Lck(Phospho Tyr192) Polyclonal Antibody has been rigorously validated for its specificity and sensitivity through various experimental approaches, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits minimal cross-reactivity with non-phosphorylated Lck and other related proteins, ensuring accurate and reliable results.

This antibody is supplied as a liquid formulation, ready for immediate use in various applications. It is compatible with a wide range of experimental techniques, including immunohistochemistry, flow cytometry, and ELISA. The Lck(Phospho Tyr192) Polyclonal Antibody is provided in a convenient size and concentration, allowing for multiple experiments and minimizing waste.

In summary, the Lck(Phospho Tyr192) Polyclonal Antibody is a valuable tool for researchers studying T-cell biology and signaling pathways. Its high specificity, sensitivity, and versatility make it an essential component in the investigation of Lck phosphorylation events.