LAT2 Polyclonal Antibody

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney.,induction:Activity in polarized intestinal cells is regulated by the association between SLC3A2/4F2 (in the SLC3A2/4F2-LAT2 heterodimer) and ICAM1.,miscellaneous:L-leucine transport activity inhibited by small zwitterionic amino acids (i.e. glycine, alanine, serine, threonine asparginine, glutamine, methionine, leucine, isoleucine, valine, phenylalanine, tyrosine, tryptophan, histidine and cysteine) and by glutamine and asparginine. Methionine uptake was inhibited by the L-system substrates L-leucine, 2-amino-bicyclo-(2,2,1)-heptane-2-carboxylate (BCH), L-cysteine and by the MeHg-L-cysteine complex and structurally related S-ethyl-L-cysteine. MeHg-L-cysteine uptake is inhibited by L-methionine, L-leucine, BCH and S-ethyl-L-cysteine. L-leucine uptake was inhibited by L-CNSO.,Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.,subcellular location:Localized to the cytoplasm when expressed alone but when coexpressed with SLC3A2/4F2hc, is localized to the plasma membrane. Colocalized with SLC3A2/4F2hc at the basolateral membrane of kidney cortex proximal tubules and small intestine epithelia of the villi.,subunit:Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.,tissue specificity:Strongest expression is observed in kidney and moderate expression in placenta and brain, followed by liver, prostate, testis, ovary, lymph node, thymus, spleen, skeletal muscle and heart. Also expressed in fetal liver as well as in the retinal pigment epithelial cell line ARPE-19 and the intestinal epithelial cell line Caco-2.,

The LAT2 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of LAT2 protein in various biological samples. This antibody has been rigorously tested and validated to ensure its reliability and accuracy in experimental settings.

LAT2, also known as linker for activation of T cells family member 2, is a transmembrane protein that plays a crucial role in T cell activation and immune response regulation. It is primarily expressed in lymphoid tissues and is involved in the formation of immunological synapses between T cells and antigen-presenting cells.

The LAT2 Polyclonal Antibody has been developed using advanced immunization techniques and exhibits exceptional affinity and specificity towards the target protein. It has been extensively characterized using various assays, including Western blotting, immunohistochemistry, and immunofluorescence, to ensure its optimal performance across different applications.

This antibody offers numerous advantages, including its high sensitivity, low background noise, and broad reactivity across multiple species. It is suitable for use in both research and clinical settings, enabling the investigation of LAT2 protein expression and localization in various tissues and cell types.

The LAT2 Polyclonal Antibody is supplied as a liquid formulation, making it convenient and easy to use. It is provided in a ready-to-use format, eliminating the need for additional reagents or preparation steps. The antibody is stable and can be stored at -20°C, ensuring its long-term usability.

In summary, the LAT2 Polyclonal Antibody is a reliable and efficient tool for the detection and quantification of LAT2 protein. Its high specificity, sensitivity, and versatility make it an invaluable asset for researchers and clinicians studying T cell activation and immune response regulation.